While certain symptoms of Parkinson’s disease are often noted in describing it – tremors, slowness of movement and rigidity – a Michigan State University professor says no one case is the same. “If you’ve met one person with Parkinson’s disease, you’ve met one person,” explained Tim Collier, Ph.D., a professor in the Translational Science & Molecular Medicine department at MSU's College of Human Medicine. Collier is also the Edwin A. Brophy endowed chair in central nervous system research at the college.
Collier outlined research taking place in Grand Rapids at this year’s Let's Talk Health Faith in Wellness luncheon, held Tuesday, June 11. He was joined by Susan Woolner, a certified patient experience professional at Mercy Health Hauenstein Neurosciences. The annual luncheon is part of a weeklong series of events put on by Blue Cross and designed to spark community conversations about health. The Greater Grand Rapids NAACP also supports the week's events. Current treatment Treatment for Parkinson’s disease hasn’t evolved much since the 1960s, Collier said. Because the disease depletes dopamine in the brain, the dopamine-boosting drug levodopa is often prescribed. Deep brain stimulation, which Collier described as being “like a pacemaker for the brain” is currently used as a treatment of last resort, usually 12-14 years after diagnosis. Consistent exercise is also recommended for people with Parkinson’s. Collier said studies have shown that when Parkinson’s patients exercise for about 150 minutes per week – or 2 ½ hours – they show a smaller decline in mobility and quality of life. He said intense exercise typically produces greater benefits, but any exercise is beneficial. “What you need to do is find something you like and will stick with, that’s safe,” Collier said. Ongoing research There are many research projects focused on various aspects of Parkinson’s disease at MSU’s Grand Rapids campus.
Using deep brain stimulation earlier could be protective. Early stage trials of deep brain stimulation in patients have been shown to be safe and offer promising results that offering this treatment sooner after diagnosis could halt progression of the disease’s symptoms by slowing the degeneration of dopamine neurons in the brain.
Personalized medicine could help guide better treatment. There’s a growth factor in the brain called brain-derived neurotrophic factor, which helps neurons survive and grow. About 40% of the population has a variation in the coding of the gene for BDNF, which results in reduced levels of the growth factor. In people with Parkinson’s disease, having this variation can indicate they won’t respond as well to dopamine-replenishing therapies. Research suggests that testing for the gene variant through a simple saliva test could help doctors recommend better treatment options for affected patients.
Other research is focused on limiting the side effects of levodopa. Most people with Parkinson’s disease develop side effects within 5-10 years of starting treatment. Collier is working on research to repurpose FDA-approved drugs to slow the progression of the disease.
Patient advocacy Woolner focused on patient advocacy in her talk. She thinks numbers putting people with Parkinson’s disease in Michigan at about 30,000 could be low due to people not being able to access proper diagnosis and treatment. Since depression can be an early symptom, this could also hinder people from seeking treatment. Other early non-motor symptoms include:
Apathy and anxiety
Tingling or pain
Blood pressure or urinary problems
Digestion issues, including constipation
She urged people with Parkinson’s disease and their loved ones or caregivers to passionately advocate for the treatment that’s best for them. “Find out what is best to keep you functioning,” she said. Support is an important component in effectively managing the disease, she said, recommending that those with Parkinson’s or their caregivers seek out peer mentors, support groups and community resources. She also strongly recommended being seen by a movement disorders specialist. If you found this post helpful, you might also enjoy:
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